Table 1.
Tetraspanin associations in pathogen-recognition receptors and APC functions.
| Tetraspanin | Interacting molecule | Cell type | Function | Reference |
|---|---|---|---|---|
| CD9 | TLR4–CD14 complex | Macrophages | Regulates LPS-induced signaling | (45) |
| CD36 | Macrophages | Mediates CD36–integrin complex formation and ligand-bound internalization and signaling | (46, 47) | |
| FcγR | Macrophages | Interacts with and regulates FcγR-mediated immune responses | (47, 48) | |
| FcϵRI | Monocytes and DCs | Association at the membrane | (49) | |
| MHC-II | DCs | Association at the membrane | (50–52) | |
| CD81 | Rac1 | DCs | Controls TLR2- and IFNAR-mediated bacterial recognition | (53) |
| CD36 | Macrophages | Regulates CD36–integrin complex formation, ligand-bound internalization and signaling | (46, 47) | |
| FcϵRI | Monocytes and DCs | Association at the membrane | (49) | |
| BCR | B cells | Controls CD19 surface expression and BCR complex downstream signaling | (3, 54) | |
| MHC-II | DCs | Association at the membrane | (50, 51) | |
| CD37 | Dectin-1 | Macrophages | Controls dectin-1 stabilization at the membrane and signaling triggered by dectin-1 recognition of yeast cell walls | (41) |
| MHC-II | B cells and DCs | Associates with and regulates MHC-II-dependent antigen presentation | (55, 56) | |
| CD63 | Dectin-1 | DCs | Associates with dectin-1 and regulates yeast phagocytosis | (40, 43) |
| MHC-II | DCs | Associates with peptide-loaded MHC-II and controls its surface expression | (50, 51, 57, 58) | |
| CD82 | MHC-II | Macrophages and DCs | Association at MHC-II-enriched compartments, and fungal and bacterial phagosomes | (44, 50, 51, 57) |
| CD53 | MHC-II | B cells, DCs | Association at the membrane | (50, 55) |
| CD151 | CD80, CD86 | DCs | Regulates costimulation during Ag presentation | (56) |