Table 2. Results of overall and subgroups analyses.
| Overall and subgroups | Number of Studies | Heterogeneity |
Model | Meta-analysis |
||
|---|---|---|---|---|---|---|
| p | I2(%) | OR(95%CI) | p for OR | |||
| A vs. G | 16 | 0.34 | 9.61 | Fixed | 1.23(1.04–1.44) | 0.01 |
| HWE (Yes) | 14 | 0.32 | 12.35 | Fixed | 1.26(1.06–1.49) | 0.01 |
| HWE (No) | 2 | 0.28 | 15.29 | Fixed | 1.04(0.65–1.65) | 0.88 |
| Population-based | 11 | 0.56 | 0 | Fixed | 1.31(1.07–1.61) | 0.01 |
| Hospital-based | 5 | 0.14 | 41.6 | Fixed | 1.10(0.85–1.43) | 0.47 |
| Smoking (Mixed) | 7 | 0.45 | 0 | Fixed | 1.19(0.95–1.48) | 0.13 |
| Smoking (No) | 6 | 0.09 | 47.68 | Random | 1.39(0.88–2.17) | 0.15 |
| Asian | 3 | 0.74 | 0 | Fixed | 1.39(1.01–1.92) | 0.04 |
| Brazilian | 2 | 0.62 | 0 | Fixed | 0.70(0.40–1.18) | 0.18 |
| Caucasian | 9 | 0.3 | 15.37 | Fixed | 1.27(1.04–1.55) | 0.02 |
| Chileans | 1 | / | / | / | 1.12(0.31–4.11) | 0.86 |
| AA vs. GG | 15 | 0.14 | 36.5 | Fixed | 2.07(1.11–3.87) | 0.02 |
| HWE (Yes) | 13 | 0.14 | 36.5 | Fixed | 2.07(1.11–3.87) | 0.02 |
| HWE (No) | 2 | – | – | – | – | – |
| Population-based | 10 | 0.27 | 22.38 | Fixed | 2.73(1.01–7.35) | 0.05 |
| Hospital-based | 5 | 0.04 | 75.6 | Random | 1.15(0.17–7.87) | 0.89 |
| Smoking (Mixed) | 7 | 0.11 | 50.97 | Random | 2.18(0.56–8.44) | 0.26 |
| Smoking (No) | 6 | 0.18 | 38.63 | Fixed | 1.95(0.64–6.00) | 0.24 |
| Asian | 3 | 1 | 0 | Fixed | 2.71(1.09–6.73) | 0.03 |
| Brazilian | 2 | 1 | 0 | Fixed | 0.37(0.07–2.02) | 0.25 |
| Caucasian | 9 | 0.27 | 22.38 | Fixed | 2.73(1.01–7.35) | 0.05 |
| Chileans | 1 | / | / | / | – | – |
| AG vs. GG | 15 | 0.22 | 20.56 | Fixed | 1.06(0.85–1.32) | 0.62 |
| HWE (Yes) | 13 | 0.2 | 24.15 | Fixed | 1.06(0.83–1.34) | 0.64 |
| HWE (No) | 2 | 0.18 | 44.51 | Fixed | 1.06(0.60–1.87) | 0.85 |
| Population-based | 10 | 0.19 | 28.16 | Fixed | 1.15(0.85–1.55) | 0.35 |
| Hospital-based | 5 | 0.35 | 9.53 | Fixed | 0.96(0.69–1.32) | 0.79 |
| Smoking (Mixed) | 7 | 0.56 | 0 | Fixed | 1.01(0.77–1.32) | 0.96 |
| Smoking (No) | 6 | 0.04 | 57.69 | Random | 1.21(0.81–1.82) | 0.34 |
| Asian | 3 | 0.32 | 12.67 | Fixed | 1.14(0.77–1.69) | 0.52 |
| Brazilian | 2 | 0.92 | 0 | Fixed | 0.75(0.40–1.42) | 0.38 |
| Caucasian | 9 | 0.08 | 42.99 | Random | 1.06(0.70–1.59) | 0.79 |
| Chileans | 1 | / | / | / | 1.14(0.29–4.45) | 0.85 |
| AA vs. AG+GG | 15 | 0.13 | 37.95 | Fixed | 2.09(1.13–3.86) | 0.02 |
| HWE (Yes) | 13 | 0.13 | 37.95 | Fixed | 2.09(1.13–3.86) | 0.02 |
| HWE (No) | 2 | – | – | – | – | – |
| Population-based | 10 | 0.22 | 29.33 | Fixed | 2.65(0.99–7.04) | 0.05 |
| Hospital-based | 5 | 0.05 | 73.93 | Random | 1.22(0.20–7.62) | 0.83 |
| Smoking (Mixed) | 7 | 0.11 | 49.57 | Fixed | 2.20(1.05–4.61) | 0.04 |
| Smoking (No) | 6 | 0.15 | 43.12 | Fixed | 1.86(0.62–5.63) | 0.27 |
| Asian | 3 | 1 | 0 | Fixed | 2.75(1.12–6.75) | 0.03 |
| Brazilian | 2 | 1 | 0 | Fixed | 0.42(0.08–2.19) | 0.3 |
| Caucasian | 9 | 0.22 | 29.33 | Fixed | 2.65(0.99–7.04) | 0.05 |
| Chileans | 1 | / | / | / | – | – |
| AA+AG vs. GG | 15 | 0.91 | 0 | Fixed | 1.06(0.85–1.31) | 0.61 |
| HWE (Yes) | 13 | 0.93 | 0 | Fixed | 1.06(0.84–1.33) | 0.64 |
| HWE (No) | 2 | 0.18 | 44.51 | Fixed | 1.06(0.60–1.87) | 0.85 |
| Population-based | 10 | 0.99 | 0 | Fixed | 1.08(0.80–1.45) | 0.62 |
| Hospital-based | 5 | 0.24 | 26.65 | Fixed | 1.03(0.76–1.41) | 0.84 |
| Smoking (Mixed) | 7 | 0.58 | 0 | Fixed | 1.10(0.85–1.43) | 0.45 |
| Smoking (No) | 6 | 0.83 | 0 | Fixed | 0.98(0.65–1.46) | 0.91 |
| Asian | 3 | 0.52 | 0 | Fixed | 1.29(0.89–1.88) | 0.18 |
| Brazilian | 2 | 0.74 | 0 | Fixed | 0.70(0.38–1.30) | 0.26 |
| Caucasian | 9 | 0.92 | 0 | Fixed | 1.02(0.76–1.37) | 0.89 |
| Chileans | 1 | / | / | Fixed | 1.14(0.29–4.45) | 0.85 |
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium; –, the AA frequency = 0; /, only one study included.