Table 1. Study cohorts.
| Group | Number | Route of administration | Adenovirus dose vp (vp/kg) | Human equivalent dosea vp (vp/kg) |
|---|---|---|---|---|
| 1 | 24 | Intraprostatic | 3 × 106 (1.28 × 108) | 1 × 1010 (1.25 × 108) |
| 2 | 24 | Intraprostatic | 3 × 107 (1.28 × 109) | 1 × 1011 (1.25 × 109) |
| 3 | 24 | Intraprostatic | 3 × 108 (1.28 × 1010) | 1 × 1012 (1.25 × 1010) |
| 4 | 24 | Intravenous | 3 × 108 (1.28 × 1010) | 1 × 1012 (1.25 × 1010) |
| 5 | 24 | Intraprostatic | Saline | NA |
a
Assuming 80 kg (175 lbs.) human. Mean weight of 120 mice at the time of adenovirus injection was 23.4 g.