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. Author manuscript; available in PMC: 2016 Jan 11.
Published in final edited form as: Drug Metab Pharmacokinet. 2010 Oct 22;26(1):3–14. doi: 10.2133/dmpk.dmpk-10-rv-062

Table 6.

Drugs withdrawn because of hepatotoxicity.3235)

Time period Drug Total
number
Pre-1960 Cinchophen, iproniazid 2
1960–1969 Benziodarone, ibufenac, phenoxypropazine, pipamazine, xenazoic acid 5
1970–1979 Fenclozic acid, mebanazine, nialamide, oxyphenisatin 4
1980–1989 Benoxaprofen, clomacron, clometacin, cyclofenil, exifone, glafenine, isaxonine, nitrofazole, nomifensine, perhexiline, suloctidyl, tienilic acid, zimelidine 13
1990–1999 Alpidem, amineptine, bendazac, benzarone, bromfenac, chlormezanone, dilevalol, ebrotidine, fipexide, moxisylyte, niperotidine, pirprofen, tolrestat 13
2000–2006 Ximelagatran, pemoline, nefazodone, troglitazone 4