. Author manuscript; available in PMC: 2016 Dec 11.

Published in final edited form as: ACS Infect Dis. 2015 Aug 2;1(12):604–614. doi: 10.1021/acsinfecdis.5b00063

Table 2.

In Vitro Characterization of Representative Compounds

compound	enzyme IC₅₀ (nM)		MIC₉₀ (µM)		Tox₅₀ (µM)	selectivity index (Tox₅₀/MIC₉₀)	intracell MIC₉₀ (µM)	cell health^a (µM)
compound	Mtb	human	wt	DHFR-oe	HepG2	selectivity index (Tox₅₀/MIC₉₀)	intracell MIC₉₀ (µM)	cell health^a (µM)
WR99210	14^a	9.0	1–2	15–30	40	20	9.7	10/19/25
PDP-1	8.2	6.7	1.25	30	40	32	1.2	nd^c
PQD-1	7.1	6.8	0.50	>2	10	20	0.7	nd
DPt-1	49.1	382.1	2–8	250	>50	>17	28	200/200/200
DQn-1	6.2	7.6	0.03	1.0	>50	>1000	0.05	200/200/200
trimetrexate^b	17	nd	6.25	>100	nd	nd	nd	nd

Nuclear morphology/membrane permeability/mitochondrial potential.

Data from Nixon et al.¹⁵

nd, not determined.