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Physicochemical Properties and Initial DMPK of Representative Compounds
| compound | mol wt (g/mol) | cLogP | LE | LLE | PFI | CLND solubility (µM) | in vitro clearance in mouse microsomes (mg/mL·g) |
|---|---|---|---|---|---|---|---|
| WR99210 | 432.14 | 4.00 | 0.46 | 4.00 | 4.9 | 373 | <0.5 |
| PDP-1 | 380.67 | 3.51 | 0.52 | 4.49 | 8.1 | 52 | >30 |
| PQD-1 | 314.34 | 2.53 | 0.46 | 5.47 | 5.8 | 12 | <0.5 |
| DPt-1 | 310.35 | 2.68 | 0.42 | 4.32 | 6.6 | 30 | nd |
| DQn-1 | 343.77 | 2.83 | 0.46 | 5.17 | 3.1 | 401 | <0.5 |
