Table 2.

Functional MRI studies of decision-making in eating disorders

Author	Participants	Stimuli	Neural differences
Marsh et al87,*	BN 20 HC 20	Simon spatial incompatibility task to assess self-regulation/impulsivity.	BN: less activation of ILPFC, inferior frontal gyri, ACC, putamen, caudate. More dACC activation during errors in BN.
Marsh et al88,*	teenBN 18 teenHC 18	Simon spatial incompatibility task to assess self-regulation and conflict resolution.	BN: less activity in frontostriatal circuit during correct trials, including left inferior frontal gyrus, posterior cingulate, and superior frontal gyrus.
Marsh et al90,*	BN 34 HC 34	Structural analysis of brain surfaces in subjects from above two studies using Simon Spatial Incompatibility.	Reduced gray matter in frontal and temporal regions in BN. Further, reduction of inferior frontal gyri correlated with symptom severity measures in BN.
Lock et al91	AN-BP/BN 13 AN-R 14 HC 13	Go/No-Go paradigm comparing correct-No-Go with correct Go.	AN-BP/BN group has more activity in bilateral precentral gyrus, ACC, and middle and superior temporal gyri than HC; also more hypothalamus and DLPFC than AN-R and HC.
Decker et al80	AN-R 13 AN-BP 10 HC 23	Delayed discounting task before and after weight restoration of patients.	When underweight, AN with less striatum and dACC. When weight-restored, AN with increase striatum, dACC, PFC, parietal HC opposite effect with repetition of task.
Kullmann et al92	AN 12 HC-Athlete 12 HC 14	Go/No-Go paradigm to examine response inhibition using food/nonfood images and people active/rest.	Food/nonfood: hypoactive right putamen in AN. Active/rest: AN group with increased PFC response inhibition; somatosensory cortex correlates with exercise commitment.

Note:

^*Similar tasks presented adjacent to these studies.

Abbreviations: ACC, anterior cingulate cortex; AN, anorexia nervosa; AN-BP, binge–purge anorexia nervosa; AN-R, restricting anorexia nervosa; BED, binge-eating disorder; BN, bulimia nervosa; dACC, dorsal anterior cingulate cortex; DLPFC, dorsolateral prefrontal cortex; HC, healthy controls; ILPFC, inferiolateral prefrontal cortex; MRI, magnetic resonance imaging; PFC, prefrontal cortex; recBN, recovered bulimia nervosa; recAN, recovered anorexia nervosa; teenHC, teenagers healthy control; teenBN, teenagers with bulimia nervosa; R ant, right anterior.