Evidence on value of various definitions of sub-diabetes

	Diabetes				Arterial disease				Retinal disease
	Predicts	Effect of lifestyle interventions	Effect of drugs		Predicts	Effect of lifestyle interventions	Effect of drugs		Predicts
Impaired glucose tolerance (7.8-11.1 mmol/L)*	+++	+++ (delays)	+++ (disguises)				?		+
		+ (prevents)	+ (prevents)
Impaired fasting glucose (6.1-6.9 mmol/L)	++	?	(+)†		+	?	?		?
Expanded impaired fasting glucose (5.6-6.9 mmol/L)	+	?	?		+	?	?		?
Borderline HbA­1c (6.0-6.4%)	++	?	?		+	?	?		?
Expanded borderline HbA1c (5.7-6.4%)	+	?	?		+	?	?		?

*Two hours after 75 g glucose load.

† The DREAM Study included 14% of subjects with impaired fasting glucose in whom rosiglitazone showed comparable effects to those with impaired glucose tolerance at the end of the intervention,³⁷ although this group was not reported separately after drug washout.⁴⁵