Fig 5 Kinome profile for axitinib, pazopanib, sunitinib, and sorafenib. The branches represent the known human kinases. Red circles represent targets for the various agents and the size of the circle indicates the inhibitory potency of the kinase (circle sizes are inversely proportional to fold selectivity ratios). Axitinib is an example of a highly specific kinase inhibitor, whereas sunitinib has a considerably broader range of action. Darker red dots provide contrast where overlapping dots are present. Adapted, with permission, from McTigue and colleagues⁸⁷