Figure 1.

Mossy fiber LTP in vivo. (i) Schematic illustration of stimulating (upper) and recording electrode (lower) positions in the coronal plane of the hippocampus with corresponding stereotaxic co-ordinates (adapted from Paxinos and Watson's Atlas, The Rat Brain in Stereotaxic Coordinates, 6th ed., ²⁰⁰⁶, Elsevier.). (ii) Examples of electrically induced lesions illustrating stimulating (a) and recording (b) electrode positions in the hippocampus from a MF-LTP experiment, (iii) fEPSP elicited by stimulating from dentate gyrus (a) to CA3 (b); Spike evoked by antidromic stimulation of the granule cells in CA3 (b) and recorded in dentate gyrus (a), (iv) fEPSP recordings remain stable for >140 min (n = 5). Vehicle injection (i.h.) has no effect on fEPSP slope. Insets are representative fEPSPs at the indicated time points from individual experiments. [Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.]