Fig. 2.

Longitudinal changes in FA and ADC. a Acute and subacute FA measurements, and b acute and subacute ADC measurements for each ROI. All data are displayed as mean +/− SD. Acute time period is defined as post-trauma days 1–7. Subacute period is defined as post-trauma day 8 until discharge from rehabilitation hospital. Acute and subacute diffusion parameters were compared using a two-tailed paired Wilcoxon signed-rank test. *p < 0.05; **p < 0.01. Of note, the longitudinal FA change in CB was within the 95 % precision limit for the healthy control’s FA measurements in this region. The acute CSF ADC value (2729 +/− 461 x 10⁻⁶ mm²/s) and the subacute CSF ADC value (3049 +/− 231 x 10⁻⁶ mm²/s) are not shown in panel b because of the difference in scale between CSF ADC values and all other ADC values. Abbreviations: ACR, anterior corona radiata; CB, cingulum bundle; CP, cerebral peduncle; CS, centrum semiovale; CSF, cerebrospinal fluid; DL MB, dorsolateral midbrain; ILF, inferior longitudinal fasciculus; PL IC, posterior limb of internal capsule; UF, uncinate fasciculus