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. 2016 Jan 11;17:1. doi: 10.1186/s13059-015-0866-z

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© Haber et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Recent positive selection in Europe and Asia. Change over time in the allele frequency of variants involved in adult lactose tolerance (rs4988235 for LCT), skin pigmentation (rs1426654 for SLC24A5) and immunity (rs4833095 for TLR1 and rs9302752 for NOD2) observed from aDNA (colored solid lines). Allele frequencies in ancient populations are replotted from Allentoft et al. [32]. The black dotted lines represent predictions from theoretical models of selection based only on present-day population information. We assume that the initial frequency of the derived alleles in Eurasians in the past was similar to that in present-day Near Easterners. Increase in the frequency of these alleles was thought to have started in Paleolithic times (SLC24A5) or in Neolithic times (TLR1, NOD2 and LCT)