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. 2015 Jul 29;41(3):736–750. doi: 10.1038/npp.2015.199

Figure 5.

Figure 5

Viral-mediated overexpression of 4.1N-CTD in the nucleus accumbens shell has no effect on the reinstatement of cocaine seeking. (a) Representative image of peak eGFP fluorescence in the nucleus accumbens 3 days following HSV 4.1N-CTD infusion. (b) Increases in 4.1N protein expression induced by HSV 4.1N-CTD as assessed with western blot (see inset). Total active and inactive lever responding (mean±SEM) 3 days or 1 week following intra-shell microinfusion of HSV eGFP or HSV 4.1N-CTD is shown in panels c and d, respectively. Note that the active lever responding to a systemic injection of cocaine (10 mg/kg, i.p.) does not differ between treatments at either time point. The inset in panel d depicts cannula placements for all shell microinjections. There were 5–13 rats per treatment.