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. 2015 Aug 12;41(3):802–810. doi: 10.1038/npp.2015.206

Figure 4.

Figure 4

Clstn2−/− mice show hyperactivity but no differences in anxiety or depression related behaviors. (a) Clstn2−/− and Clstn2+/− mice showed increased locomotor activity in the open field (assessed by travel distance) as compared with WT. One-way ANOVA, F(2, 27)=16.3, P<0.0001, and **P<0.05, ***P<0.001 by Bonferroni post hoc test comparing with WT; n=9–11 mice per group. Mice of all genotypes spent a similar amount of time in the center of the open field (F(2,27)=0.98, P>0.05). (b) There was no effect of genotype on percent of time spent in each arm in the elevated plus maze. Two-way ANOVA, effect of genotype F(2, 81)=0.0000014, P=1.0, effect of compartment F(2,81)=309.1, P<0.0001, interaction F(4,81)=1.12, P=0.35, n=8–13 mice per group. Nor was there any effect of genotype on total number of entries into each arm, number of passages from one enclosed arm to another, number of head-dips, number of risk assessment postures, or the number of explorations of an open arm end (not shown; all P>0.10). (c) There was no difference between genotypes in the forced swim test. One-way ANOVA, F(2,27)=0.48, P=0.62, n=8–13 mice per group.