Table 2. Summary of Results for Regional Brain Activation and Amygdala Functional Connectivity in PTSD Relative to Healthy Youth.

Contrast	Effect	Region	BA	Voxels	X	Y	Z	Peak t
Regional brain activation
Threat-neutral images	PTSD>healthy	Left dACC	32, 24, 6	565	−6	18	38	5.01
		Left PCG	6, 44	455	−52	4	10	5.79
		Thalamus	—	273	−6	−20	16	3.92
		Right PCG/STG	44, 22	225	52	12	2	4.23
	Age: PTSD<healthy	Right pMC	6	531	14	16	64	−5.02
		Right IPL	40	280	46	−42	40	−4.24
		Left pMC	6	278	−22	0	48	−3.92
		Left dmPFC	9	189	−4	54	30	−4.2
Functional connectivity (PPI)
Right amygdala seed: threat-neutral images	Age: PTSD>healthy	Right dmPFC	9	82	10	58	34	4.18
Left amygdala seed: threat-neutral images	PTSD<healthy	Bilateral rACC/dmPFC	32, 10, 9	93	−6	46	12	−4.22
		Left dmPFC	9, 10	90	−14	58	8	−4.22
	Age: PTSD<healthy	Right vmPFC	11	117	8	46	−18	−4.31
		Left vmPFC	11	81	−8	46	−16	−3.79

Abbreviations: dACC, dorsal anterior cingulate cortex; dmPFC, dorsomedial prefrontal cortex; IPL, inferior parietal lobule; MFG, middle frontal gyrus; PCG, precentral gyrus; pMC, premotor cortex; PPI, psychophysiological interaction; rACC, rostral anterior cingulate cortex; STG, superior temporal gyrus; vmPFC, ventromedial prefrontal cortex.

Peak coordinates (X, Y, Z) are in MNI space, LPI orientation. All contrasts were PTSD minus healthy; thus, a positive t-statistic indicates PTSD>healthy. No group by sex effects were observed in any analysis.