Table 1. Twenty-one Gene Co-Expression Modules that Showed Consistent Correlation with Bipolar Disorder (BD).

Module	BD correlation in NISC1/NISC2	BD association p-value	BD association FDR	Enrichment of differentially expressed genes	GWAS enrichment
Yellow	+/+	1.94E-03	0.017	2.20E-16	ns
Light yellow	+/+	2.52E-03	0.017	ns	ns
Sky blue	+/+	2.76E-03	0.017	1.66E-05	ns
Dark turquoise	−/−	3.58E-03	0.017	ns	3.00E-04
Dark grey	+/+	3.66E-03	0.017	3.53E-09	ns
Purple	+/+	0.005	0.018	2.20E-16	9.00E-04
Dark orange	−/−	0.008	0.024	0.031	ns
Royal blue	+/+	0.012	0.032	0.024	ns
Red	−/−	0.015	0.035	2.54E-05	8.30E-03
Green	−/−	0.024	0.050	2.20E-16	5.80E-03
Turquoise	−/−	0.026	0.050	1.79E-06	ns
Light cyan	+/+	0.036	ns	ns	5.30E-03
White	+/+	0.049	ns	ns	ns
Saddle brown	+/+	ns	ns	ns	9.10E-03
Dark olive green	+/+	ns	ns	ns	ns
Salmon	−/−	ns	ns	ns	0.034
Pale turquoise	−/−	ns	ns	0.033	ns
Blue	−/−	ns	ns	ns	ns
Dark green	−/−	ns	ns	ns	0.016
Dark red	+/+	ns	ns	No overlap	ns
Midnight blue	−/−	ns	ns	ns	ns

Abbreviation: ns, not significant.

‘+' and ‘−' represent increased and decreased gene expression in bipolar disorder, respectively.