Table 1. Twenty-one Gene Co-Expression Modules that Showed Consistent Correlation with Bipolar Disorder (BD).
Module | BD correlation in NISC1/NISC2 | BD association p-value | BD association FDR | Enrichment of differentially expressed genes | GWAS enrichment |
---|---|---|---|---|---|
Yellow | +/+ | 1.94E-03 | 0.017 | 2.20E-16 | ns |
Light yellow | +/+ | 2.52E-03 | 0.017 | ns | ns |
Sky blue | +/+ | 2.76E-03 | 0.017 | 1.66E-05 | ns |
Dark turquoise | −/− | 3.58E-03 | 0.017 | ns | 3.00E-04 |
Dark grey | +/+ | 3.66E-03 | 0.017 | 3.53E-09 | ns |
Purple | +/+ | 0.005 | 0.018 | 2.20E-16 | 9.00E-04 |
Dark orange | −/− | 0.008 | 0.024 | 0.031 | ns |
Royal blue | +/+ | 0.012 | 0.032 | 0.024 | ns |
Red | −/− | 0.015 | 0.035 | 2.54E-05 | 8.30E-03 |
Green | −/− | 0.024 | 0.050 | 2.20E-16 | 5.80E-03 |
Turquoise | −/− | 0.026 | 0.050 | 1.79E-06 | ns |
Light cyan | +/+ | 0.036 | ns | ns | 5.30E-03 |
White | +/+ | 0.049 | ns | ns | ns |
Saddle brown | +/+ | ns | ns | ns | 9.10E-03 |
Dark olive green | +/+ | ns | ns | ns | ns |
Salmon | −/− | ns | ns | ns | 0.034 |
Pale turquoise | −/− | ns | ns | 0.033 | ns |
Blue | −/− | ns | ns | ns | ns |
Dark green | −/− | ns | ns | ns | 0.016 |
Dark red | +/+ | ns | ns | No overlap | ns |
Midnight blue | −/− | ns | ns | ns | ns |
Abbreviation: ns, not significant.
‘+' and ‘−' represent increased and decreased gene expression in bipolar disorder, respectively.