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. Author manuscript; available in PMC: 2017 Jan 8.
Published in final edited form as: ACS Infect Dis. 2015 Oct 17;2(1):82–92. doi: 10.1021/acsinfecdis.5b00108

Figure 1.

Figure 1

Schematic of our model that captures the dynamics of HIV from seminal fluid diffusing across a cervicovaginal mucus (CVM) layer containing HIV-binding IgG to reach the underlying vaginal epithelium. To reduce infection, IgG must bind to HIV in sufficient quantities to neutralize or to trap the virions in mucus before HIV virions successfully penetrate CVM. Our model captures the tandem effects of IgG–antigen binding kinetics (kon, koff) as well as IgG–mucin interactions (mon, moff).