Figure 1. Acute LPS challenge promoted a transient sickness response that was resolved within 48 h.
Adult BALB/c mice were injected (i.p.) with saline or LPS (10 µg). Over a 72 h time course, A) body weight, B) locomotor activity, and C) social exploratory behavior were determined. D) IL-6 protein levels were determined in plasma collected 2, 4, 12, 24, and 48 h later. Data expressed as percent change from baseline. Means with (*) are different from saline controls (p<0.05) and means with (+) tend to be different from saline controls (p=0.06–0.10).