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Fig. 2. : the immune response underlying asymptomatic infection. Aspects of the
immune response of asymptomatic malaria carriers were compared to symptomatic
patients. This response was didactically divided into immune cells including T
regulatory (Treg) cells, CD4+ T-cells, B-cells, neutrophils, and monocytes
(MOs) and biomarkers related to inflammation [interleukin (IL)-10, transforming
growth factor (TGF)-β, prostaglandin E2 (PGE2), interferon (IFN)-γ, and tumour
necrosis factor (TNF) and the haeme pathway [haeme, soluble CD163 (sCD163),
haeme oxygenase-1 (HO-1), and superoxide dismutase (SOD)-1]. Additionally,
molecular networks in the context of asymptomatic infection illustrate the use
of methods of data integration in immunology. ADCI: antibody-dependent cellular
inhibition; ADRB: antibody-dependent respiratory burst.