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. Author manuscript; available in PMC: 2016 Jan 11.
Published in final edited form as: Curr Top Dev Biol. 2014;107:269–292. doi: 10.1016/B978-0-12-416022-4.00010-X

Table 10.1.

Markers for HPCs

Marker Diseases (models) Species References
A6 DDC, CDE, viral hepatitis, deletion of Ddb1 Mouse Endo et al. (2012), Fan et al. (2012), and Tonkin, Knight, Curtis, Abraham, and Yeoh (2008)
AFP Acute necrotizing hepatitis, HCV, primary biliary cirrhosis Human Spee et al. (2010)
2-AAF/PH Rat Jensen et al. (2004) and Yovchev et al. (2008)
CD44 Acute necrotizing hepatitis, HCV, primary biliary cirrhosis Human Spee et al. (2010)
2-AAF/PH Rat Yovchev et al. (2008)
DDC, deletion of Ddb1 Mouse Endo et al. (2012) and Shin et al. (2011)
CD133 Alcoholic hepatitis, acute necrotizing hepatitis, HCV, HBV, primary biliary cirrhosis Human Porretti et al. (2010), Sancho-Bru et al. (2012), and Spee et al. (2010)
2-AAF/PH Rat Yovchev et al. (2008)
DDC, ANIT, CCl4 Mouse Dorrell et al. (2011), Rountree, Barsky, et al. (2007), and Suzuki et al. (2008)
CK7 Pediatric nonalcoholic fatty liver disease, alcoholic hepatitis, HCV, primary biliary cirrhosis Human Nobili et al. (2012), Sancho-Bru et al. (2012), and Spee et al. (2010)
2-AAF/PH Rat Yovchev et al. (2008)
DDC Mouse Suzuki et al. (2008)
CK19 Acetaminophen-induced necrosis, genetic hemochromatosis, alcoholic liver disease, HCV, HBV, acute necrotizing hepatitis, primary biliary cirrhosis Human Feng et al. (2012), Lowes et al. (1999), Spee et al. (2010), and Theise et al. (1999)
2-AAF/PH Rat Dusabineza et al. (2012) and Yovchev et al. (2008)
DDC, CDE, deletion of Ddb1 Mouse Carpentier et al. (2011), Endo et al. (2012), Fan et al. (2012), and Takase et al. (2013)
CLDN4 2-AAF/PH Rat Yovchev et al. (2008)
Deletion of Ddb1 Mouse Endo et al. (2012)
DLK1 Retrorsine, 2-AAF/PH Rat Jensen et al. (2004)
EPCAM Alcoholic hepatitis, HCV, HBV Human Porretti et al. (2010) and Sancho-Bru et al. (2012)
2-AAF/PH Rat Yovchev et al. (2008)
DDC, deletion of Ddb1 Mouse Endo et al. (2012), Fan et al. (2012), Okabe et al. (2009), Shin et al. (2011), and Takase et al. (2013)
Foxl1 BDL, DDC Mouse Sackett, Li, et al., (2009) and Shin et al. (2011)
GGT 2-AAF/PH, GalN Rat Dabeva and Shafritz (1993) and Yovchev et al. (2008)
ITGB4 AAF-PH Rat Yovchev et al. (2008)
Deletion of Ddb1 Mouse Endo et al. (2012)
ITGA6 HCV, HBV Human Porretti et al. (2010)
2-AAF/PH Rat Yovchev et al. (2008)
Lgr5 CCl4, DDC, MCDE Mouse Huch et al. (2013)
M2PK Genetic hemochromatosis, alcoholic liver disease, HCV Human Lowes et al. (1999)
CDE Mouse Davies, Knight, Tian, Yeoh, and Olynyk (2006)
NCAM HCV, HBV, acute necrotizing hepatitis, primary biliary cirrhosis Human Porretti et al. (2010) and Spee et al. (2010)
OPN DDC, CDE, CCl4, PH Mouse Carpentier et al. (2011) and Espanol-Suner et al. (2012)
Sox9 DDC, CDE Mouse Carpentier et al. (2011)
Trop2 DDC, CDE Mouse Carpentier et al. (2011), Okabe et al. (2009), and Shin et al. (2011)

2-AAF, 2-acetaminofluorene; ANIT, alpha-naphthylisothiocyanate; CCl4, carbon tetrachloride; CDE, choline-deficient, ethionine-supplemented diet; Ddb1, damaged DNA-binding protein 1; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; GalN, D-galactosamine; HBV, Hepatitis B virus; HCV, Hepatitis C virus; MCDE, methionine choline-deficient diet supplemented with ethionine; PH, partial hepatectomy.