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. Author manuscript; available in PMC: 2016 Jun 14.
Published in final edited form as: Nature. 2015 Dec 14;529(7584):92–96. doi: 10.1038/nature16483

Fig 2. RNA-seq transcriptional profile of isolated neurons reveals IIS/FOXO neuronal transcriptome.

Fig 2

A) Volcano plot of daf-2-regulated, daf-16-dependent up- (red) and down-regulated (green) neuronal genes (p<0.05). B) Comparison of whole-worm (Class I)8 vs neuronal-IIS/FOXO targets. P-values: hypergeometric distributions. C–E) Short-term associative memory (STAM) assays. C) Schematic of STAM assay and chemotaxis profiles of daf-2 treated with (C) sod-3 or (D, E) neuronal IIS/FOXO target gene RNAi. D) Learning indices relative to control RNAi at 3h post-training of daf-2 treated with adult-only (green) or whole life (blue) neuronal IIS/FOXO target gene RNAi. Mean ± SEM, *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001, two-way repeated measures ANOVA, Bonferroni post hoc tests.

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