Extended Data Fig 5.

A) The different classes of neuronal IIS/FOXO genes shown in Figure 2B were analyzed for DBE and DAE sequences in the 1kb upstream promoter regions. The genome-wide % of DBE and DAE occurrences across the 1kb promoters of all gene-encoding regions is reported. Comparison of whole-worm (Class I)⁸ vs neuronal-IIS/FOXO-regulated targets. P-values: hypergeometric distributions. B) GO terms of Class I whole worm⁸ vs. neuronal-IIS up-regulated genes (left) and Class II whole worm⁸ vs neuronal-IIS down-regulated genes (right) (Supplementary Table 5).