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Effects of hidden subphenotypes on GWAS. (A) Classical CC GWAS wherein heterogeneity in the case population is hidden or is not accounted for; can recover only shared causal markers (SNP3) (B) Subphenotyping approach to the same data recovers both shared (SNP3) and subphenotype causal-specific markers (SNP2, SNP4 and SNP5)
