Table 2. Pharmacokinetics of dapoxetine 30 and 60 mg (80,81).
| Dapoxetine 30 mg | Dapoxetine 60 mg | |
|---|---|---|
| Cmax (ng/mL) | 297 | 498 |
| Tmax (h) | 1.01 | 1.27 |
| T1/2 (h) | 17.2 | 18.2 |
| Initial T1/2 (h) | 1.31 | 1.42 |
| Terminal T1/2 (h) | 18.7 | 21.9 |
| T50% Cmax (h) | 1.92 | 2.14 |
| AUC 0-24 h (ng·h/mL) | 1,110 | 2,070 |
| AUC∞ (ng·h/mL) | 1,390 | 2,640 |
| Effect of high fat meal | ||
| Cmax (ng/mL) (fasted) | – | 443 |
| Cmax (ng/mL) (high-fat meal) | – | 398 |
| Tmax (h) (fasted) | – | 1.30 |
| Tmax (h) (high-fat meal) | – | 1.83 |
| T1/2 (h) (fasted) | – | 16.3 |
| T1/2 (h) (high-fat meal) | – | 17.8 |
| AUC∞ (ng·h/mL) (fasted) | – | 2,190 |
| AUC∞ (ng·h/mL) (high-fat meal) | – | 2,450 |
Abbreviations: Cmax, maximum plasma concentration; Tmax, time to peak concentration; T1/2, half-life; AUC, area under the curve.