Table 1. Castrate resistant prostate cancer treatment side effects.

Drug	Median OS (months)	S/E
Mitoxantrone	No improvement, but improved symptom palliation	Dyspnea, mucositis, cytopenias, cardiac dysfunction
Docetaxel	2.9 (mitoxantrone/prednisone)	Neutropenia, neuropathy, fatigue, N/V, alopecia, diarrhea, dyspnea, tearing, peripheral edema, nose bleeds
Sipuleucel-T	4.1 (placebo/prednisone)	Chills, HA, fever
Abiraterone	4.6 (post-docetaxel, placebo/prednisone)	Fatigue, arthralgia, peripheral edema, anemia, back pain, bone pain, hypokalemia
Cabazitaxel	2.4 (post-docetaxel, mitoxantrone/prednisone)	Neutropenia, diarrhea, N/V
Enzalutamide	4.8 (post-docetaxel, placebo/prednisone)	Fatigue, diarrhea, hot flashes, seizures
Radium-223 dichloride	2.8 (placebo)	Nausea, vomiting, peripheral edema

OS, overall survival; S/E, side effects; N/V, nausea, vomiting; HA, headache.