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LS mean change in IIEF-EF score over time (error bars present the 95% confidence interval). IIEF-EF, International Index of Erectile Function-Erectile Function domain; LS, least squares; MCID, minimal clinically important difference; MMRM, mixed-effect model for repeated measures; OaD, once a day; PLC, placebo; PRN, on demand; TAD, tadalafil. Reproduced with permission from Elsevier (48).
