Table 1.

Correlation between clinicopathological variables and Nectin-4 expression in HCC

Variables	Total	Nectin-4 protein expression		χ2	P-value
		Negative	Positive
Sex
Male	66	19	47	1.445	0.229
Female	21	9	12
Age (years)
≤50	36	13	23	0.434	0.510
>50	51	15	36
HBsAg status
Negative	25	10	15	0.982	0.322
Positive	62	18	44
Liver cirrhosis
Absent	14	6	8	0.871	0.351
Present	73	22	51
Child–Pugh grade
A	68	21	47	0.242	0.623
B	19	7	12
AFP (ng/mL)
≤20	32	10	22	0.020	0.887
>20	55	18	37
Tumor size (cm)
≤5	33	6	27	4.776	0.029
>5	54	22	32
Status of metastasis
Absent	58	14	44	5.161	0.023
Present	29	14	15
Tumor capsula
Complete	43	16	27	0.984	0.321
None	44	12	32
Vascular invasion
Absent	43	19	24	5.612	0.018
Present	44	9	35
Edmondson grade
I–II	45	17	28	1.336	0.248
III–IV	42	11	31
TNM stage
I–II	52	23	29	8.595	0.003
III–IV	35	5	30

Abbreviations: AFP, α-fetoprotein; HBsAg, hepatitis B surface antigen; HCC, hepatocellular carcinoma; TNM, tumor-node-metastasis.