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. 2014 Mar;3(1):41–49. doi: 10.3978/j.issn.2223-4683.2014.02.02

Table 2. Common pharmacologic treatments for retrograde ejaculation (35).

Medication Class Dose/frequency Efficacy, % (1) Side effects
Pseudoephedrine Alpha receptor agonist 60 mg 4 times daily or 120 mg twice daily 30 Hypertension, abdominal pain, nausea/vomiting
Brompheniramine Anti-histamine 16-24 mg daily 38 Anticholinergic side effects
Imipramine Tricyclic antidepressant 25 mg twice daily 65 Anticholinergic side effects including cardiac dysrhythmias
Midodrine Alpha receptor agonist 15 mg daily 62 Headache, anxiety, dry mouth
Ephedrine Indirect adrenergic receptor agonist 50-100 mg daily 20 Tachycardia, hypertension, nausea, headache