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. Author manuscript; available in PMC: 2016 Jan 11.
Published in final edited form as: Free Radic Biol Med. 2012 Apr 19;53(3):618–628. doi: 10.1016/j.freeradbiomed.2012.03.025

Table 2.

LS12 mitochondrial phenotype relative to the parental GM10115 cells.

Endpoint Change Reference
Reactive oxygen species ↑ [8,15,16]
Mitochondrial contribution to cellular H2O2 ↑ [15]
Number of mitochondria (MitoTracker) NC [15]
↑ [7]
Amount of mitochondrial DNA NC [15]
State 3 respiration ↓ [15]
State 4 respiration NC [15]
Complex IV (cytochrome oxidase) activity ↓ [15]
MnSOD protein level NC [15]
MnSOD activity ↓ [15]
NC [6]
Intracellular H2O2 ↑ [6]
Extracellular H2O2 ↑ [6]
Intracellular superoxide ↑ [6]
Catalase protein level and activity NC [6]
GPx protein level and activity NC [6]
CuZnSOD activity NC [6]
Mitochondrial membrane potential NC [7]
ATP levels NC [7]
SQR activity ↑ [7]
Soluble and bound SDHB protein levels ↑ [7]

MnSOD, manganese superoxide dismutase; GPx, glutathione peroxidase; CuZn-SOD, copper–zinc superoxide dismutase; SQR, succinate quinone oxidoreductase; SDHB, succinate dehydrogenase B; NC, no change.