Table 3.
Association between genotypes and Grade ≥ 3 RP
| Polymorphism and Genotype | No. of event | No. of total | Univariate analysis | Multivariate analysis | Pc | ||||
|---|---|---|---|---|---|---|---|---|---|
| HR | 95% Cl | P | HR | 95% Cl | P | ||||
| AKT2: rs33933140 | |||||||||
| AA | 18 | 64 | 1 | 1 | |||||
| GA+GG | 19 | 197 | 0.309 | 0.162–0.589 | 3.6E–4 | 0.272 | 0.140–0.530 | 1.3E–4 | 9.1E–4 |
| AKT2: rs11880261 | |||||||||
| CC | 9 | 117 | 1 | 1 | |||||
| CT + TT | 28 | 144 | 2.726 | 1.286–5.778 | 0.009 | 2.950 | 1.380–6.305 | 0.005 | 0.025 |
| PI3CA: rs9838117 | |||||||||
| TT | 4 | 8 | 1 | 1 | |||||
| GT + GG | 33 | 253 | 0.191 | 0.067–0.540 | 0.002 | 0.132 | 0.042–0.416 | 0.001 | 0.006 |
Multiple analyses in this table were adjusted for all of the factors listed in Table 1. HR, hazard ratio; CI, confidence interval.
P c: P‐value corrected by Benjamini and Hochberg False Discovery Rate correction.