Table 2.
Sex‐specific associations of serum leptin and C‐reactive protein (CRP) with cancer death in the NHANES III
| N cancer death/N total | HR (95% CI) | ||
|---|---|---|---|
| Model 1a | Model 2b | ||
| Men | |||
| Leptin (μg/L) | |||
| Low | 49/909 | 1.0 (Reference) | 1.0 (Reference) |
| Moderate | 71/962 | 0.87 (0.51–1.49) | 0.75 (0.43–1.35) |
| High | 79/964 | 0.86 (0.50–1.47) | 0.60 (0.26–1.33) |
| P trend | 0.60 | 0.22 | |
| CRP (mg/L) | |||
| Low | 195/2047 | 1.0 (Reference) | 1.0 (Reference) |
| Moderate | 56/596 | 1.33 (0.82–2.18) | 1.31 (0.85–2.04) |
| High | 34/192 | 2.98 (1.57–5.64) | 2.90 (1.52–5.53) |
| P trend | 0.003 | 0.002 | |
| P interaction leptin and CRP | 0.13 | 0.13 | |
| Women | |||
| Leptin (μg/L) | |||
| Low | 54/1081 | 1.0 (Reference) | 1.0 (Reference) |
| Moderate | 71/1096 | 1.19 (0.74–1.91) | 0.81 (0.51–1.30) |
| High | 61/1128 | 0.93 (0.57–1.51) | 0.40 (0.24–0.68) |
| P trend | 0.80 | 0.0007 | |
| CRP (mg/L) | |||
| Low | 103/2027 | 1.0 (Reference) | 1.0 (Reference) |
| Moderate | 58/914 | 1.41 (0.84–2.38) | 1.19 (0.67–2.11) |
| High | 25/364 | 1.10 (0.61–1.99) | 0.86 (0.45–1.63) |
| P trend | 0.28 | 0.99 | |
| P interaction leptin and CRP | 0.72 | 0.81 | |
a
Adjusted for age (continuous) and waist circumference, race/ethnicity, poverty‐to‐income ratio (PIR), tobacco smoking, alcohol consumption, and vigorous physical activity.
b
Adjusted for age (continuous) and waist circumference, race/ethnicity, PIR, tobacco smoking, alcohol consumption, vigorous physical activity, body mass index (continuous) and waist circumference (continuous), and waist circumference.