Table 1.

Estimated prevalence of heterozygous careers of DNA repair disorders

DNA repair gene	Responsible disease	Estimated prevalence
ATM	Ataxia telangiectasia	1:100
WRN	Werner syndrome	1:100
FANCA, FANCC, FANCG	Fanconi anemia	1:181 (in the USA)
MLH1, MSH2, MSH6, PMS2, EPCAM	Lynch syndrome	1:370 (or higher)
BRCA1, BRCA2	Hereditary breast ovarian cancer syndrome	1:400–800