Table 3.
Variations of pulmonary function tests according to GOLD criteria
| GOLD criteria | Parameters | Pre-SBRT | Post-SBRT | Pre-Post | P values Pre vs. Post |
|---|---|---|---|---|---|
| Mild to moderate COPD (I, II) n = 6 | FEV1.0, L | 1.40 (0.85–2.16) | 1.30 (0.61–2.24) | 0.14 (−0.08–0.38) | 0.15 |
| FEV1.0 %predicted | 61.2 (50.2–89.4) | 55.6 (29.4–95.0) | 5.5 (−5.7–22.2) | 0.38 | |
| VC, L | 2.24 (1.73–3.37) | 2.23 (1.33–3.12) | 0.16 (−0.09–0.47) | 0.11 | |
| VC %predicted | 79.6 (52.1–105.1) | 76.5 (46.5–104.1) | 3.0 (−6.3–17.2) | 0.29 | |
| Severe COPD (III, IV) n = 10 | FEV1.0, L | 0.92 (0.58–1.30) | 0.88 (0.47–1.39) | 0.02 (−0.16–0.44) | 0.45 |
| FEV1.0 %predicted | 36.0 (19.3–44.1) | 33.5 (21.2–48.1) | 2.4 (−6.2–7.9) | 0.80 | |
| VC, L | 2.68 (1.72–3.57) | 2.71 (1.59–3.76) | −0.07 (−0.31–0.78) | 0.94 | |
| VC %predicted | 73.9 (49.4–109.7) | 76.0 (51.5–117.7) | −2.0 (−9.7–22.1) | 0.70 | |
| Overall cases n = 16 | FEV1.0, L | 1.12 (0.58–2.16) | 1.02 (0.47–2.24) | 0.10 (−0.16–0.44) | 0.11 |
| FEV1.0 %predicted | 42.9 (19.3–89.4) | 42.9 (21.2–95.0) | <0.01 (−6.2–22.2) | 0.47 | |
| VC, L | 2.62 (1.72–3.57) | 2.68 (1.33–3.76) | −0.07 (−0.31–0.78) | 0.33 | |
| VC %predicted | 77.0 (49.4–109.7) | 76.0 (46.5–117.7) | 1.04 (−9.7–22.1) | 0.70 |
All data given as median (range) unless otherwise indicated. COPD = chronic obstructive pulmonary disease, FEV1.0 = forced expiratory volume in 1 s, GOLD = global Initiative for Chronic Obstructive Lung Disease, SBRT = stereotactic body radiotherapy, VC = vital capacity.