Table 3. Odds ratios for different exposure definitions of treated-to-target urate levels.

	Cases In target / Not in target	Controls In target / Not in target	Crude OR (95% CI)	Adjusted* OR (95% CI)
Urate threshold for treat-to-target
< 0.20 mmol/l	16 / 522	22 / 1769	2.17 (1.07–4.43)	2.29 (1.05–4.97)
< 0.30 mmol/l	94 / 444	317 / 1474	0.88 (0.66–1.16)	1.11 (0.81–1.52)
< 0.36 mmol/l	197 / 341	728 / 1063	0.77 (0.62–0.95)	1.01 (0.79–1.28)
< 0.42 mmol/l	326 / 212	1231 / 560	0.63 (0.51–0.78)	0.94 (0.73–1.20)
< 0.48 mmol/l	437 / 101	1559 / 232	0.60 (0.46–0.79)	0.88 (0.65–1.20)
Percent change from baseline urate level
0–10	508 / 30	1665 / 126	1.27 (0.83–1.94)	1.24 (0.78–1.98)
> 10	467 / 71	1501 / 290	1.18 (0.88–1.58)	1.22 (0.89–1.68)
> 20	387 / 151	1212 / 579	1.15 (0.91–1.44)	1.07 (0.83–1.38)
> 30	268 / 270	794 / 997	1.10 (0.89–1.35)	1.07 (0.85–1.36)
> 40	160 / 378	398 / 1393	1.32 (1.05–1.66)	1.15 (0.88–1.50)
> 50	71 / 467	153 / 1638	1.57 (1.15–2.16)	1.43 (1.00–2.04)
> 60	30 / 508	47 / 1744	2.17 (1.31–3.61)	1.97 (1.13–3.46)

*) Adjusted by variables presented in S1 Table