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. 2016 Jan 11;11(1):e0146641. doi: 10.1371/journal.pone.0146641

Fig 6. D5R and CCKBR interaction in mouse kidney.

Fig 6

(A) CCKBR protein expression in PMFs is increased in D5R gene knockout mice (D5R-/-), relative to wild-type littermates (D5R+/+). (B) D5R protein expression in PMFs is increased in CCKBR gene knockout mice (CCKBR-/-) relative to wild-type littermates (CCKBR+/+). (C) Effect of the D1R and D5R agonist fenoldopam (Fen, 1mg/kg/day, one week) on the renal membrane protein expression of CCKBR in BALB/c mice fed high salt (HS) diet. NS = normal salt. (D) Effect of gastrin (Gas, 10g/kg/day, one week) on the renal membrane protein expression of D5R in BALB/c mice on high salt (HS) diet. NS = normal salt. *P<0.05, n = 3–5 per group, Student’s t test. All immunoblotting results are expressed as relative density units (DU). Sample loading amount was quantified by bicinchoninic acid assay. Immunoblots of D5R and CCKBR are shown in the inset.