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. 2016 Jan 11;11(1):e0146326. doi: 10.1371/journal.pone.0146326

Fig 3. TLR9 stimulation augments atherosclerosis.

Fig 3

ApoE-/- mice were fed a cholesterol rich diet for 7 weeks and treated 3 times a week with 18nM CpG ODN s.c. for 6 weeks (a). Chronic stimulation of TLR9 in ApoE-/- mice led to a significant increase in aortic atherosclerotic plaque size compared to vehicle treated mice (b, quantitative and representative Oil-red O image; n = 9). MOMA-2 stained atherosclerotic plaque were similar compared to vehicle treated mice (c, quantification and representative image). Data are presented as mean±SEM. Statistical analysis was performed using 2-tailed, unpaired students t-test. Scale bar 200μm in b and c. **p<0.001.