Fig 6. Chaperones Hsp12p and Hsp26p are not required for increased proliferation of cells lacking mtDNA upon Pde2p overexpression.

(A) HSP12 and HSP26 transcripts are overexpressed upon PKA inhibition in ρ⁰ cells. HSP12 and HSP26 transcript abundance within ρ⁰ cells upon overexpression of Pde2p, overproduction of Tip41p, or upon maintenance of empty vector pRS426 were normalized to gene expression in ρ⁺ cells carrying an empty vector. (B) Neither Hsp12p nor Hsp26p are individually responsible for the benefits provided by Pde2p overexpression to cells deleted of mtDNA. Strains CDD463 (WT), CDD542 (hsp12Δ), CDD534 (hsp26Δ) were treated as in Fig 1A.