Table 4. Relevant GO biological processes in blood as affected by selection for RFI.

GO terma		Genesb
Overexpressed genes in low RFI line compared with high RFI line
GO:0006414	Translational elongation	RPSA, EEF1A1, RPL14, RPL15, RPL35, RPL23A, SELT, RPS3, RPS25, RPS18, RPL6, RPS13, RPL10, RPL10A, RPS21, UBA52, RPS23
Underexpressed genes in low RFI line compared with high RFI line
GO:0006952	Defense response	KYNU, NMI, FGR, LY86, CCR1, CLU, TLR1, TLR2, CXCR2, PRDX1, IL10, IL10RB, BCL2, TAP1, CSF3R, NFATC4, CD24, THBS1, BLNK, F12, TLR10, PTGER3, LY96, BECN1, HCK, IL1RN, HLA-C, C4BPB, HLA-B, CD40, C4BPA, STAT3, CD84, CD83, CD55, CD19, HIST2H2BE, CLEC7A, CLEC5A, CD14
GO:0045321	Leukocyte activation	ZBTB32, BST2, TLR1, TLR2, CXCR2, CD40, TPD52, SKAP2, IL10, CBLB, PKNOX1, PSEN1, ULBP1, BCL2, BCL11A, MS4A1, ADAM17, BCL6, CLEC7A, CD24, SYK, BLNK, ADAM9
GO:0050727	Regulation of inflammatory response	F12, ADRB2, PTGS2, SERPINF1, TGM2, CMA1, BCL6, JAK2, CD24, IL10
GO:0044092	Negative regulation of molecular function	NF1, PKIG, NPR3, PKIA, PROX1, PDCD4, PSMB8, PSMB9, SH3BP5, SPRY2, ADRB2, PSEN1, PSME2, CDKN2D, RGS4, PSMA3, UBC, SORT1, JAK2, UBE2D1, BUB3, DHCR24
GO:0019882	Antigen processing and presentation	HLA-H, ULBP1, HLA-DRB3, HLA-A, ERAP1, HLA-C, CD1A, HLA-B, HLA-DOB, PSMB8, PSMB9
GO:0006916	Anti-apoptosis	BECN1, SPHK1, CLU, BIRC3, ANXA4, IL10, TNFSF13B, PSEN1, BCL2, CDKN2D, TGM2, UBC, ADAM17, THBS1, DHCR24
GO:0002684	Positive regulation of immune system process	CLU, TLR2, C4BPB, CD40, C4BPA, CD83, CBLB, CD55, CD19, TNFSF13B, PSEN1, ADAM17, BCL6, CD24, CLEC7A, THBS1, SYK
GO:0030155	Regulation of cell adhesion	VAV3, GSN, BCL2, NF1, CCDC80, TGM2, BCL6, JAK2, CD24, THBS1, TPM1, ADAM9

^aGene ontology (GO) identification number and term of the biological process. Benjamini-Hochberg adjusted P-value varied from 0.1 and 8.10⁻⁰⁵.

^bUnique genes included in each pathway.