Figure 1.

Mucosal toxicity. Significant dose-related effect between cumulative dose of gemcitabine and incidence of severe acute mucositis was observed for chemoradiotherapy with gemcitabine and cisplatin (red bubbles) but not for chemoradiotherapy with gemcitabine alone (gray bubbles). However, taken together, a plateau phase above a cumulative dose of 300 mg/m² (roughly corresponding to 50 mg/m² per week) suggests that no clear dose-effect correlation for mucosal toxicity exists in that segment of the curve.