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. Author manuscript; available in PMC: 2016 Jan 12.
Published in final edited form as: Biochem Pharmacol. 2014 Feb 22;89(1):12–19. doi: 10.1016/j.bcp.2014.02.010

Figure 1. Scheme showing the effects of heparanase (Hpa) involving tumor/microenviroment interactions.

Figure 1

1) cleavage of heparan sulfate (HS) by heparanase (as indicated by the solid arrows) and release of heparan sulfate-bound growth factors (GF) from proteoglycans; 2) growth factor-mediated signaling; 3) proangiogenic signaling; 4) disassembly of extracellular matrix and release of HS-bound growth factors.