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. 1978 Oct;33(5):603–607. doi: 10.1136/thx.33.5.603

Pulmonary manifestations of hypogammaglobulinaemia.

R J Dukes, E C Rosenow 3rd, P E Hermans
PMCID: PMC470942  PMID: 725827

Abstract

Fifty-five patients with late-onset idiopathic immunoglobulin deficiency were studied and upper or lower respiratory tract infections were encountered in about 90%. Cylindrical bronchiectasis was shown in all of the 21 patients in whom bronchograms were done. A thymoma was found in four patients. Three patients had diffuse interstitial pulmonary disease--two with proved and one with presumed lymphocytic interstitial pneumonitis. Five patients had no evidence of pulmonary disease, including two patients with long-standing late-onset immunoglobulin deficiency who had essentially no serum immunoglobulins. This small subgroup of patients with immunoglobulin dificiency without severe pulmonary infections cannot be explained in the context of current understanding of immunoglobulin deficiency. Thirty-two patients were followed up for long enough for the response to treatment to be assessed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Asherson G. L. Immunodeficiency disorders. Practitioner. 1975 Apr;214(1282):494–501. [PubMed] [Google Scholar]
  2. Choi Y. S., Biggar W. D., Good R. A. Biosynthesis and secretion of immunoglobulins by peripheral-blood lymphocytes in severe hypogammaglobulinaemia. Lancet. 1972 May 27;1(7761):1149–1152. doi: 10.1016/s0140-6736(72)91374-8. [DOI] [PubMed] [Google Scholar]
  3. Fudenberg H., Good R. A., Goodman H. C., Hitzig W., Kunkel H. G., Roitt I. M., Rosen F. S., Rowe D. S., Seligmann M., Soothill J. R. Primary immunodeficiencies. Report of a World Health Organization Committee. Pediatrics. 1971 May;47(5):927–946. [PubMed] [Google Scholar]
  4. GAFNI J., MICHAELI D., HELLER H. Idiopathic acquired agammaglobulinemia associated with thymoma. Report of two cases and review of the literature. N Engl J Med. 1960 Sep 15;263:536–541. doi: 10.1056/NEJM196009152631103. [DOI] [PubMed] [Google Scholar]
  5. Geha R. S., Schneeberger E., Merler E., Rosen F. S. Heterogeneity of "acquired" or common variable agammaglobulinemia. N Engl J Med. 1974 Jul 4;291(1):1–6. doi: 10.1056/NEJM197407042910101. [DOI] [PubMed] [Google Scholar]
  6. Hermans P. E., Diaz-Buxo J. A., Stobo J. D. Idiopathic late-onset immunoglobulin deficiency. Clinical observations in 50 patients. Am J Med. 1976 Aug;61(2):221–237. doi: 10.1016/0002-9343(76)90173-x. [DOI] [PubMed] [Google Scholar]
  7. Kaltreider H. B. Expression of immune mechanisms in the lung. Am Rev Respir Dis. 1976 Mar;113(3):347–379. doi: 10.1164/arrd.1976.113.3.347. [DOI] [PubMed] [Google Scholar]
  8. Liebow A. A., Carrington C. B. Diffuse pulmonary lymphoreticular infiltrations associated with dysproteinemia. Med Clin North Am. 1973 May;57(3):809–843. doi: 10.1016/s0025-7125(16)32278-7. [DOI] [PubMed] [Google Scholar]
  9. Spitler L. E., Levin A. S., Fudenberg H. H. Agammaglobulinemia, absent delayed sensitivity and lymphopenia without infections. A demonstration of immunologic unknowns. Am J Med. 1973 Mar;54(3):371–377. doi: 10.1016/0002-9343(73)90032-6. [DOI] [PubMed] [Google Scholar]
  10. Waldmann T. A., Durm M., Broder S., Blackman M., Blaese R. M., Strober W. Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet. 1974 Sep 14;2(7881):609–613. doi: 10.1016/s0140-6736(74)91940-0. [DOI] [PubMed] [Google Scholar]

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