Table 4.
Summary of associations between genes of interleukins and leprosy.
| Genes | Population | SNP allelic group/genotype ID/haplotype | Phenotype | Compared to | OR/(rr) | P-value | Conclusion |
|---|---|---|---|---|---|---|---|
| IL-6 | Brazilian | (CC) rs1800795 | ENL | NR | 2.41 | 0.03 | Susceptibility (83) |
| IL-6 | Brazilian | (CC + CG) rs1800795 | ENL | NR | 3.71 | 0.005 | Susceptibility (83) |
| IL-6 | Brazilian | (AA) rs2069832 | ENL | NR | 2.71 | 0.007 | Susceptibility (83) |
| IL-6 | Brazilian | (AA + AG) rs2069832 | ENL | NR | 4.00 | 0.002 | Susceptibility (83) |
| IL-6 | Brazilian | (GG) rs2069840 | ENL | NR | 0.44 | 0.03 | Protection (83) |
| IL-6 | Brazilian | (GG + CG) rs2069840 | ENL | NR | 0.39 | 0.04 | Protection (83) |
| IL-6 | Brazilian | (GG) rs2069845 | ENL | NR | 1.92 | 0.04 | Susceptibility (83) |
| IL-6 | Brazilian | (GG + AG) rs2069845 | ENL | NR | 2.59 | 0.045 | Susceptibility (83) |
| IL-12B | Indian | 3′UTR2.2 | Leprosy | Controls | – | 0.001 | Protection (85) |
| IL-12 | Mexican | 3′UTR 1188 A/C (CC) | LL | Controls | – | <0.05 | Susceptibility (86) |
| IL-12 | Mexican | 3′UTR 1188 A/C (AC) | LL | Controls | – | <0.05 | Protection (86) |
| IL12B | Chinese | rs6871626 | Leprosy | Controls | 0.75 | 3.95 × 1018 | Protection (88) |
| IL18RAP | Chinese | rs2058660 | Leprosy | Controls | 1.30 | 4.57 × 1019 | Susceptibility (88) |
| IL12B | Indian | (AA vs. AC + CC) rs2853694 | Leprosy | Controls | 1.42 | 2.6 × 104 | Susceptibility (89) |
| IL-10 | Brazilian | 819T | Leprosy | Controls | 1.35 | 0.03 | Susceptibility (91) |
| IL-10 | Brazilian | 819TT | Leprosy | Controls | 2.64 | 0.04 | Susceptibility (69) |
| IL-10 | Brazilian | 819T | PB | MB | 2.28 | 0.01 | Susceptibility (69) |
| IL-10 | Colombian | (C/C and C/T) rs1800871 | Leprosy | Controls | 4.34 | <0.001 | Susceptibility (92) |
| IL-10 | Colombian | (C/C and C/A) rs1800872 | Leprosy | Controls | 4.3 | <0.001 | Susceptibility (92) |
| IL-10 | Colombian | Haplotype (819C-519C) | Leprosy | Controls | 4.34 | <0.001 | Susceptibility (92) |
| IL-10 | Colombian | 1082A-819C-592C | Leprosy | Controls | 6.25 | <0.001 | Susceptibility (92) |
| IL-10 | Brazilian | -3575-2849-2763 | Leprosy | Controls | – | 0.044 | Susceptibility (93) |
| IL-10 | Brazilian | -3575A-2849G-2763C | Leprosy | Controls | 0.35 | 0.005 | Protection (93) |
| IL-10 | Indian | -819 (TT vs. CT + CC) | Leprosy | Controls | 2.50 | <0.005 | Susceptibility (94) |
| IL-10 | Indian | -819 (CC vs. CT + TT) | Leprosy | Controls | 0.59 | 0.005 | Protection (94) |
| IL-10 | Indian | -592 (AA vs. CA + CC) | Leprosy | Controls | 2.43 | <0.005 | Susceptibility (94) |
| IL-10 | Indian | -592 (CC vs. CA + AA) | Leprosy | Controls | 0.60 | 0.006 | Protection (94) |
| IL-10 | Indian | -3575T-2849G-2763C-1082A-819C-592C | Leprosy | Controls | 0.58 | 0.01 | Protection (94) |
| IL-10 | Brazilian | 1082G-819C-592C | LL | Controls | – | 0.02 | Protection (70) |
MB, multibacillary; PB, paucibacillary; BB, mid-borderline; BL, borderline lepromatous; BB, borderline tuberculoid; LL, lepromatous leprosy; TT, tuberculoid leprosy; per se, leprosy independent of specific clinical manifestations; ENL, type 2 reactions or erythema nodosum leprosum; RR, type I or reversal reaction; NR, leprosy who did not have reaction; UTR, untranslated region; OR, odds ratio; rr, relative risk; P values; SNPs, single-nucleotide polymorphisms.