Table 1.

Use of SP600125 as a possible therapeutic target in Alzheimer’s disease.

	Experimental model	Findings	Reference
In vitro	F11 cells	Blockade of βAPP dimerization and ASK1 (MAP3K5) mediated neuronal cell death	Hashimoto et al., 2003
	Hippocampal cell culture from Wistar rats	Increased synaptic transmission in CA1 region	Costello and Herron, 2004
	Murine L929 fibroblasts	Block of τ phosphorylation induced by WOX1 knock-down in cell culture	Sze et al., 2004
	Primary rat microglia culture	Reduced nitrite accumulation and prevention of iNOS’s activation in glial cells	Bodles and Barger, 2005
	Primary cortical cell culture from Sprague Dawley rat	Inhibition of Bcl-w and Bcl-xL down-regulation	Yao et al., 2005
	Neuroglioma U251 cells	Inhibition of IL1β induced sAPPα release	Ma et al., 2005
	PC12 cells	Attenuation of 4-hydroxynonenal induced apoptosis	Cho et al., 2009
	Cultured human brain endothelial cells	Inhibition of Aβ induced AP-1 activation and MCP1	Vukic et al., 2009
	Primary rat hippocampal culture	Inhibition of both hetero- and autophosphorylation of JNK	Vogel et al., 2009
	Human neuroglioma H4 cells expressing Swedish APP695 or intracellular APP C99	Inhibition of staurosporine-induced Aβ	Chae et al., 2010
	SK-N-SH cell line	Reduction of passive calcium leak in endoplasmic reticulum	Das et al., 2012
	Primary cortical cell culture from Sprague Dawley rat	Reduction of morphine induced τ phosphorylation	Cao et al., 2013
	CMEC/D3 cells	Reduction of Aβ induced cytokine expression	Bamji-Mirza et al., 2014
	Primary glial culture from Swiss-Webster mice	Increase of ApoE/ABCA1 expression	Pocivavsek and Rebeck, 2009
In vivo	Male Swiss-Webster mice	Increase of ApoE/ABCA1 expression	Pocivavsek and Rebeck, 2009
	Male albino Wistar rats	Improvement of escape latency on Morris Water Maze	Ramin et al., 2011
	Drosophila sp. fly strains	Rescue of Aβ42 induced apoptosis	Hong et al., 2012
	Male C57BL/6 mice	Reduction of PS1 expression	Rahman et al., 2012
	Sprague Dawley neonatal rats	Attenuate isoflurane-induced hippocampal apoptosis mediated by JNK	Li et al., 2013
	APPswe/PS1dE9 mice	Reversion of synaptic loss, decrease of IL1β, IL6 and TNFα expression, decrease of phosphorylated τ, increase of αAPP, decrease of βAPP and Aβ oligomers and improvement of spatial learning	Zhou et al., 2015