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. 2016 Jan 12;9:517. doi: 10.3389/fncel.2015.00517

Figure 5.

Figure 5

AR-modulated p90RSK translocation depended on ERK1/2, cPKC (PKCα, PKCβ1/β2, PKCγ) phosphorylation. OGD/R were applied, and then incubation with AR (10 μM) or indicated inhibitors for indicated times. (A) Representative results of ERK1/2 and cPKC (PKCα, PKCβ1/β2, PKCγ) phosphorylation alterations in neurons experiencing 2 h AR treatment or inhibitor(s) blocking after OGD/R, and quantification data from four individual experiments were described in (B) ERK1/2, (C) PKCα, (D) PKCβ1/β2, and (E) PKCγ. (F) Representative result of p90RSK phosphorylation alterations in neurons experiencing 4 h AR treatment or inhibitor(s) blocking after OGD/R, and this quantification data were described in (G). (H) Representative result of p90RSK nucleus-cytoplasm distribution alterations in neurons experiencing 6 h AR treatment or inhibitor(s) blocking after OGD/R, and this quantification data were described in (I,J). Results mentioned-above were mean ± SD for four individual experiments which, for each condition, were performed in quadruplicate. *P < 0.05; **P < 0.01; ***P < 0.001.