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. 2016 Jan 12;6:417. doi: 10.3389/fphys.2015.00417

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Copyright © 2016 Vora, Camci and Cox.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Postnatal morphological changes in the mouse intersphenoidal synchondroses. Representative sagittal sections through the ISS at P21 (A), P28 (B), P76 (C) stained using hematoxylin, eosin (20x magnification). The hypertrophic (Hz) zone appears narrower by P28, and by P76 few hypertrophic cells can be distinguished. Mineralized tissue from the ectocranial surface of the caudal and rostral margins can be seen extending toward each other from P21 to P28 (filled arrowheads) and have bridged the ISS by P76.