Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jan 12;9:513. doi: 10.3389/fncel.2015.00513

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 Tu, Chen, McQuiston, Chiao and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Flupirtine inhibits ON-SAC but not OFF-SAC oscillation. (A) Rhythmic EPSCs of both ON- and OFF-SACs were blocked in the presence of 500 nM TTX. Note that small, irregular EPSCs were remained in OFF-SACs but not in ON-SACs. Error bars indicate the SEM. (B) Inhibition of ON-SAC but not OFF-SAC oscillation by the M-type potassium channel opener flupirtine (25 μM). Significant reduction of power at peak oscillation frequency in ON-SACs was shown in the bottom left panel, while peak frequency of OFF-SAC oscillation remained similar to control (bottom right panel). Error bars indicate the SEM.