Table 4. Connectivity Scores and Permutation BH-values of Novel Predicted Type I, II, and III Perturbagens.

Perturbagen	Cancer	Male Score	Female Score	Predicted Type	BH-value
CDK1 knockdown	LIHC	74.26	−66.44	I	<0.0001
PTPN1 knockdown	LUSC	70.89	−86.40	I	<0.0001
SMAD3 knockdown	HNSC	−79.27	82.37	II	<0.0001
HSPA4 knockdown	HNSC	−80.84	78.58	II	<0.0001
Midostaurin	All	−71.30	89.33	II	<0.0001
Etoposide	LIHC	98.76	99.70	III	0.9575
Camptothecin	LIHC	98.97	99.25	III	0.9498

The table summarizes several predictions for sex-dependent and sex-independent perturbagens. The BH-value quantifies the statistical significance of the male-female connectivity score difference, as computed by our permutation analyses (see Materials and Methods). “All” indicates that the perturbagen prediction was made on pan-cancer resistance and sensitivity signatures.