Table 5. In vivo validation of anti-influenza abilities of quercetin and chlorogenic acid.
| Treatment | Dose (mg/kg/d) | Survivors/totals (%) | Mean lung parameters |
|
|---|---|---|---|---|
| Lung Index ± S.D. (%) | Lung indexInhibition % | |||
| Zanamivir | 960 | 10/10 (100)*** | 0.65 ± 0.10*** | 34.0 |
| 480 | 9/10 (90)*** | 0.74 ± 0.11*** | 25.3 | |
| 240 | 7/10 (70)*** | 0.81 ± 0.11** | 18.3 | |
| Quercetin | 960 | 8/10 (80)** | 0.73 ± 0.07*** | 26.3 |
| 480 | 7/10 (70)** | 0.82 ± 0.03** | 16.5 | |
| 240 | 6/10 (60)* | 0.84 ± 0.02** | 14.7 | |
| Chlorogenic acid | 960 | 5/9 (55.6)* | 0.79 ± 0.10** | 20.2 |
| 480 | 5/10 (50) | 0.84 ± 0.05** | 14.4 | |
| 240 | 4/10 (40) | 0.87 ± 0.11* | 12.2 | |
| Placebo | — | 1/10 (10) | 0.99 ± 0.13 | — |
| Normal | — | 10/10 (100) | 0.56 ± 0.07 | — |
*p < 0.05, ** p < 0.01, ***p < 0.001, the values were compared with placebo controls.