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The structure of tumor antigen formulations internalized by MGL influences their processing and DC performance. (a) Recombinant Tn-MUC116TR protein remains blocked in DCs HLA class II compartment after internalization through MGL, while the shorter Tn-MUC13TR peptide (60 amino acids) is processed in HLA classes I and II compartments. (b) Effects induced on DC functions by MGL engagement with MoAb anti-MGL and Tn-MUC1 peptide.
