Table 2.
Effect of an acute administration of cannabinoid receptor ligands on oxidative stress biomarkers in the whole brains of mice. Data are presented as the means ± SEM; n = 8–12; ∗ p < 0.05, ∗∗ p < 0.01, and ∗∗∗ p < 0.001 versus vehicle-treated control group; Tukey's test.
| Drug (dose) | TAC | SOD | MDA |
|---|---|---|---|
| [mmol Fe/mL tissue] | [U/mg protein] | [μM/g wet w.] | |
| Vehicle | 249.3 ± 28.54 | 2.458 ± 0.1279 | 0.596 ± 0.027 |
| JWH 133 (0.5 mg/kg) | 275.7 ± 21.79 | 2.516 ± 0.1131 | 0.653 ± 0.029 |
| JWH 133 (1.0 mg/kg) | 385.1 ± 32.20 | 2.894 ± 0.1422 | 0.915 ± 0.056∗ |
| JWH 133 (2.0 mg/kg) | 404.0 ± 31.68∗ | 2.648 ± 0.1071 | 0.817 ± 0.080 |
| AM 630 (0.5 mg/kg) | 271.7 ± 19.89 | 2.349 ± 0.1267 | 0.611 ± 0.047 |
| AM 630 (1.0 mg/kg) | 327.4 ± 30.87 | 2.367 ± 0.1219 | 0.905 ± 0.094∗ |
| AM 630 (2.0 mg/kg) | 401.0 ± 32.44∗∗ | 2.505 ± 0.1371 | 0.880 ± 0.065 |
| AM 630 (3.0 mg/kg) | 446.4 ± 35.02∗∗∗ | 2.532 ± 0.1475 | 0.616 ± 0.030 |
| WIN 55,212-2 (1.0 mg/kg) | 418.8 ± 33.27∗∗ | 2.610 ± 0.1434 | 0.850 ± 0.059 |
| AM 251 (1.0 mg/kg) | 343.3 ± 25.83 | 2.437 ± 0.1258 | 0.900 ± 0.063∗ |
| AM 251 (3.0 mg/kg) | 371.5 ± 21.88 | 2.513 ± 0.1773 | 0.897 ± 0.078∗ |